Imaging agents
We have expertise in flexible ‘Click chemistry’ is to develop radioisotopes and fluorescent probes for positron emission tomography (PET),SPECT, MRI, optical imaging agents in personalized medicine and drug development that provide high quality images.
Services
- Conjugating one or more complexing agents with a targeting moiety, such as natural amino acids, unnatural amino acids, peptides, peptide nucleic acids, nucleotides, and analogs and derivatives thereof.
- The probe of interest is first conjugated to a chelating agent that is able to form stable complexes with the radionuclide/fluorescent of interest. This conjugation step can be carried out as part of the solid-phase synthesis, or it can be undertaken in the solution phase after synthesis and purification of the probe.
- The probe of choice can be labeled with radiometals such as Tc-99m, In-111, Rh-105, and Cu-64 with development of bioclearance agents for achieving radioactivity clearance from non-target organs.
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