BioOnco is focused on providing custom ligation(conjugation) services using solid and solution phase chemistry employing for the design and production of bio conjugates for research purpose .

We have extensive experience in handling of synthesis and isolation of various biomolecules like peptides, proteins, oligonucleotides(DNA & RNA), lipids, polymers, mono and polysaccharides, antibodies, fluorescent molecules, fatty acids, conjugation on nanoparticles, dendrimers, enzymes, metallointercalators, drugs, materials(glass, metals etc.,) and their chemo selective ligation through the linkages Amine–thiol, Thiol-thiol(disulfide), Amine–carboxylic acid(amide), Thiol-carboxylic acid, Aldehyde-oxylamine(oxime), Thiazolidine, Nativechemical ligation, Aldehyde-hydrazine(Hydrazone), Thioester(-Br+HS-C=0), Thioether(-Br+HS-), NHS- ester, Maleimide, Imidoester, schiff’s base, diazo, mannich condensation, isothourea/urea, sulfonamide, carbamate, phosphoramidate etc.

Services

• Design and Synthesis of novel conjugates and related-substances (ngram to gram level)
• Our conjugate services have applications in Protein conjugates, DNA/RNA conjugates, Drug delivery, Diagnostics (immunochemistry), Conjugated Vaccines, Biomaterials (Medical Devices, Micro array and Biochips) and Imaging agents.
• Site specific modifications of peptides, oligonucleotides, drugs, polymers, saccharides, proteins, lipids, antibodies, fatty acids, enzymes and their scaffolds.
• Generation of conjugate libraries
• Development and Validation of Analytical Methodologies
• Process Development and Optimization
• Process feasibility analysis
• New process design and route selection for new biodegradable linkers.
• Chemical development leading to economically viable and environmentally acceptable processes
• Study and optimization of reaction parameters.
• Robustness, variability, ratios, environmental impact, health and safety, waste, solvent recovery, etc.
• Technology transfer
• Impurity Isolation, Identification, Characterization and Structure Elucidation of
• Impurities
• Degradation products
• Metabolites